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Related Experiment Videos

High density lipoprotein in octogenarians.

D Ron, M Aviram, J G Brook

    Biochemical Medicine
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    High density lipoprotein (HDL) cholesterol and triglyceride levels did not differ between octogenarians with and without heart disease. Lipid profiles varied by sex, but neither HDL levels nor subfractions explained longevity in most individuals.

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    Area of Science:

    • Gerontology
    • Cardiovascular Science
    • Lipid Metabolism

    Background:

    • Investigating lipid profiles in centenarians is crucial for understanding aging and cardiovascular health.
    • High-density lipoprotein (HDL) cholesterol is associated with cardiovascular protection.
    • The lipid profiles of very elderly individuals, particularly octogenarians, remain an area of interest.

    Purpose of the Study:

    • To analyze the plasma lipid profiles, including HDL cholesterol, total cholesterol, and triglycerides, in a cohort of octogenarians.
    • To compare lipid levels between octogenarians with and without ischemic heart disease.
    • To examine gender-based differences in lipid profiles within this elderly population and investigate HDL subfractions.

    Main Methods:

    • Assay of plasma high density lipoprotein (HDL) cholesterol, total cholesterol, and total triglyceride levels in 42 octogenarians.

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  • Comparison of lipid profiles between subjects with and without ischemic heart disease.
  • Subfractionation of HDL using preparative ultracentrifugation and comparison with younger controls.

    • Main Results:

    • No significant differences in HDL cholesterol or total triglyceride levels were observed between octogenarians with and without ischemic heart disease.
    • Male octogenarians exhibited significantly lower triglyceride and total cholesterol levels compared to females.
    • HDL cholesterol levels were 10% higher in females; a bimodal distribution of HDL levels was noted, with a low peak (53 mg%) and a high peak (>70 mg%).
    • Subfractionation revealed younger individuals had higher fat-to-protein ratios in HDL-1 and HDL-2 subfractions compared to female octogenarians.

    Conclusions:

    • The hyperalphalipoproteinemia phenotype exists in longevity populations but is not prevalent enough to explain longevity in most subjects.
    • Neither the overall level of HDL particles nor the composition of HDL subfractions fully accounts for the longevity observed in the majority of this octogenarian cohort.
    • Lipid metabolism and HDL characteristics may play a complex role in aging and cardiovascular health, warranting further investigation.