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[Sequential changes of experimental cerebral infarction--CT and histological studies]
No to Shinkei = Brain and Nerve
|October 1, 1983
Summary
Hemorrhagic infarction in canine thalamus models showed distinct CT changes within 2 hours of reperfusion. Histology revealed red blood cell leakage, indicating contrast enhancement mechanisms and tissue remodeling over six weeks.
Area of Science:
- Neurology
- Radiology
- Pathology
Background:
- Hemorrhagic infarction is a common complication following ischemic stroke.
- Understanding the temporal evolution of infarcts is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the sequential changes in computed tomography (CT) and histological findings of canine thalamic infarction.
- To correlate imaging findings with pathological events during infarct evolution.
Main Methods:
- Canine thalamic infarction model induced by 6 hours of vascular occlusion followed by recirculation.
- Serial CT scans performed at various time points post-recirculation.
- Histological examination of infarctic foci at corresponding time points.
Main Results:
- Low attenuation areas on CT were visible by 2 hours post-recirculation, becoming distinct by 6 weeks.
- Contrast enhancement observed at 2 hours and between 7-14 days.
- Histology showed red blood cell extravasation at 2 hours, macrophage infiltration from day 2-5, and neovascularization between 7-14 days, contributing to contrast enhancement.
- Progressive cavity formation and tissue destruction observed from week 3 to week 6.
Conclusions:
- CT findings correlate with dynamic pathological changes in canine thalamic infarction.
- Contrast enhancement mechanisms evolve, involving initial extravasation and later neovascular leakage.
- The study provides a detailed timeline of infarct evolution from early stages to cavity formation.