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Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
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Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
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Related Experiment Video

Updated: Feb 24, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

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Hypertrichosis in PUVA-treated patients.

F H Rampen

    The British Journal of Dermatology
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Photochemotherapy, including PUVA, can cause hypertrichosis (excessive hair growth) in many patients. UV-A therapy without psoralens showed a much lower incidence of this side effect.

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    Area of Science:

    • Dermatology
    • Photobiology

    Background:

    • Photochemotherapy is a common treatment for various skin conditions.
    • Hypertrichosis is a potential side effect of certain dermatological treatments.

    Purpose of the Study:

    • To investigate the incidence of hypertrichosis in patients undergoing photochemotherapy.
    • To compare hypertrichosis rates between PUVA therapy and UV-A therapy without psoralens.

    Main Methods:

    • Retrospective analysis of patient data.
    • Observation of hypertrichosis in patients receiving PUVA therapy.
    • Observation of hypertrichosis in patients receiving UV-A therapy without psoralens.

    Main Results:

    • 65% of female patients on PUVA therapy developed moderate to severe hypertrichosis.
    • Only 14% of patients on UV-A therapy without psoralens developed hypertrichosis.
    • A significant difference in hypertrichosis incidence was observed between the two treatment groups.

    Conclusions:

    • Photochemotherapy, particularly PUVA, is associated with a high incidence of hypertrichosis.
    • UV-A therapy without systemic psoralens appears to have a lower risk of causing hypertrichosis.
    • Hypertrichosis is a notable side effect to consider in patients undergoing photochemotherapy.