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Circulating immune complexes in ankylosing spondylitis.

H Deicher, A Ebringer, S Hildebrand

British Journal of Rheumatology

|November 1, 1983

Summary

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Circulating immune complexes are present in most active ankylosing spondylitis patients. However, these immune complexes may not play a significant role in disease development due to their solubility.

Area of Science:

Immunology
Rheumatology
Clinical Chemistry

Background:

Ankylosing spondylitis (AS) is a chronic inflammatory disease.
The role of circulating immune complexes (CICs) in AS pathogenesis is not fully understood.
Previous studies have yielded conflicting results regarding CICs in AS.

Purpose of the Study:

To quantify CICs in patients with ankylosing spondylitis.
To compare CIC levels in active versus inactive disease stages.
To analyze the composition of CICs in AS and compare them to other rheumatic diseases.

Main Methods:

Sera from AS patients were analyzed for CICs.
A polyethylene glycol precipitation laser nephelometer technique was employed.
Immunoglobulin and complement protein levels (C3, C4) within CICs were assessed.

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Main Results:

Positive CIC results were observed in 52% of patients with active AS.
Only 20% of patients with inactive AS showed positive CIC results.
The immunoglobulin/complement ratio in AS CICs differed from rheumatoid arthritis and systemic lupus erythematosus, with higher C3 and C4 content.

Conclusions:

Circulating immune complexes are frequently detected in active ankylosing spondylitis.
The composition of CICs in AS, particularly the higher levels of C3 and C4, may influence their significance.
The degree of solubilization of CICs in AS suggests they might not be a primary factor in disease pathogenesis.