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The pattern electroretinogram in optic nerve demyelination.

T H Kirkham, S G Coupland

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |November 1, 1983
    PubMed
    Summary
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    The pattern electroretinogram (PERG) does not reliably detect optic nerve dysfunction in multiple sclerosis patients. Pattern visual evoked response (PVEP) is a more effective electrophysiological tool for diagnosing optic nerve disease.

    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Clinical Electrophysiology

    Background:

    • The pattern electroretinogram (PERG) is theorized to originate from the retinal ganglion cell layer.
    • Optic nerve demyelination is a common complication in multiple sclerosis (MS).

    Purpose of the Study:

    • To evaluate the utility of PERG in assessing optic nerve dysfunction in MS patients.
    • To compare the diagnostic value of PERG with pattern visual evoked potentials (PVEP).

    Main Methods:

    • Simultaneous recording of PERG and PVEP in MS patients with optic nerve demyelination.
    • Separate eye stimulation using four different check sizes.

    Main Results:

    • While some individual patients exhibited PERG abnormalities, group analysis showed no significant differences in PERG latency or amplitude compared to healthy controls.

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  • PVEP was found to be a more sensitive indicator of optic nerve disease than PERG.

    • Conclusions:

    • PERG is not a satisfactory method for reflecting optic nerve dysfunction.
    • PVEP is a more useful electrophysiological measure than PERG for detecting optic nerve disease in MS.