Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Optimal frequency locations for estimating model parameters in studies on respiratory control.

R M Engeman, G D Swanson, R H Jones

Computers and Biomedical Research, an International Journal

|December 1, 1983

Summary

Optimizing sinusoidal input frequencies significantly improves the accuracy of mathematical models describing the dynamic ventilatory response. This enhances our understanding of respiratory control physiology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Proactive integrated care improves quality of life in patients with COPD.

The European respiratory journal·2009

Same author

Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2009

Same author

Clinical effectiveness of a rehabilitation program integrating exercise, self-management, and active coping strategies for chronic knee pain: a cluster randomized trial.

Arthritis and rheumatism·2007

Same author

Economic evaluation of a rehabilitation program integrating exercise, self-management, and active coping strategies for chronic knee pain.

Arthritis and rheumatism·2007

Same author

Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugs.

Alimentary pharmacology & therapeutics·2007

Same author

Use of chaperones by obstetricians and gynaecologists: a cross-sectional survey.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2007

Area of Science:

Physiology
Mathematical Modeling
Respiratory Control

Background:

Dynamic ventilatory response to sinusoidal work rate inputs can be modeled mathematically.
Model structure provides insights into respiratory control physiology.
Accurate parameter estimation is crucial for model validity.

Purpose of the Study:

To compare the impact of arbitrary versus optimized frequency locations on parameter estimation for a complex respiratory control model.
To evaluate the effectiveness of the Fujihara model with different frequency datasets.
To determine if optimized frequencies enhance model justification.

Main Methods:

Utilized sinusoidal work rate inputs to elicit dynamic ventilatory responses.
Applied a complex mathematical model (Fujihara et al.) for parameter estimation.

Related Experiment Videos

Compared parameter estimation using arbitrary frequencies (Casaburi et al.) versus optimized frequencies (Engeman et al.).

Main Results:

The Fujihara model demonstrated significantly better justification when using data generated with optimal sinusoids.
Arbitrary frequency selections led to less reliable model parameter estimates.
Optimized frequency design is superior for accurate respiratory model development.

Conclusions:

Optimal frequency selection is critical for robust parameter estimation in respiratory control models.
The use of optimized sinusoids enhances the validity and descriptive power of mathematical models.
Future research should incorporate optimal frequency design for more accurate physiological insights.