Gastroscopic findings in systemic mastocytosis

Area of Science:

• Gastroenterology
• Hematology
• Oncology

Background:

• Systemic mastocytosis (SM) is a rare clonal neoplastic disease of myeloid cells characterized by abnormal mast cell accumulation in various organs.
• Gastrointestinal involvement is common in SM, but specific endoscopic findings are not widely recognized.
• Early diagnosis and management of SM are crucial for patient outcomes.

Observation:

• This report details the gastroscopic examination of a patient diagnosed with systemic mastocytosis.
• The endoscopic procedure identified specific mucosal abnormalities within the stomach.

Findings:

• The most characteristic gastroscopic finding in systemic mastocytosis is the presence of "urticaria-like" lesions.
• These lesions represent mast cell infiltration and degranulation within the gastric mucosa.

Implications:

• Recognizing these "urticaria-like" gastric lesions is crucial for the early diagnosis of systemic mastocytosis.
• Endoscopic surveillance can aid in identifying gastrointestinal manifestations of SM, guiding patient management.