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Related Experiment Videos

Parasympathethic effects on diet-induced thermogenesis.

K R Bryant, N J Rothwell, M J Stock

    European Journal of Pharmacology
    |November 25, 1983
    PubMed
    Summary

    Atropine enhanced the body

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    Area of Science:

    • Physiology
    • Metabolism
    • Neuroendocrinology

    Background:

    • Diet-induced thermogenesis is crucial for energy balance.
    • Brown adipose tissue (BAT) is a primary site for thermogenesis.
    • The role of the parasympathetic nervous system in BAT thermogenesis is unclear.

    Purpose of the Study:

    • To investigate the effect of atropine on diet-induced thermogenesis.
    • To explore the potential involvement of parasympathetic pathways in thermoregulation.

    Main Methods:

    • Rats were injected with atropine methyl nitrate or atropine sulphate.
    • Thermogenic responses to food were measured.
    • Acetylcholine and acetylcholinesterase activity in BAT were assessed via bioassay and histochemistry, respectively.

    Main Results:

    • Atropine administration significantly enhanced the acute thermogenic response to food in rats.
    • Neither acetylcholine nor acetylcholinesterase activity was detected in brown adipose tissue.
    • These findings suggest that BAT lacks direct parasympathetic innervation.

    Conclusions:

    • Atropine influences diet-induced thermogenesis through a non-BAT mediated pathway.
    • The parasympathetic nervous system's role in regulating BAT thermogenesis requires further investigation.
    • Atropine's mechanism of action on thermogenesis likely involves extra-BAT targets.

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