Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Self-stimulation and alcohol administered orally or intraperitoneally.

P De Witte, M F Bada

    Experimental Neurology
    |December 1, 1983
    PubMed
    Summary

    Ethanol

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction.

    Addiction biology·2016
    Same author

    Response latency of conditioned avoidance responses during generalization experiments in self-stimulated rats.

    Behavioural processes·2014
    Same author

    Critical appraisal of the revised Ghent criteria for diagnosis of Marfan syndrome.

    Clinical genetics·2011
    Same author

    Opposite effects of cholecystokinin octapeptide (CCK-8) and tetrapeptide (CCK-4) after injection into the caudal part of the nucleus accumbens or into its rostral part and the cerebral ventricles.

    Neurochemistry international·2010
    Same author

    Kelatorphan, a potent enkephalinases inhibitor, presents opposite properties when injected intracerebroventricularly or into the nucleus accumbens on intracranial self-stimulation.

    Neurochemistry international·2010
    Same author

    Similar effect of caerulein on intracranial self-stimulation in vagotomized and non-vagotomized rats.

    Neurochemistry international·2010

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Electrical self-stimulation of the brain is a key model for studying reward pathways.
    • Ethanol's effects on brain reward systems are complex and dose-dependent.

    Purpose of the Study:

    • To investigate the relationship between ethanol intake/administration and the reinforcing value of brain stimulation in rats.
    • To determine how ethanol concentration, dose, and route of administration influence brain reward.

    Main Methods:

    • Rats underwent electrical brain self-stimulation.
    • Ethanol was administered orally (drinking solution) or intraperitoneally (injections) at varying concentrations and doses.
    • Reinforcing value was measured by time spent self-stimulating and bar presses.

    Main Results:

    • Low doses of ethanol (oral or IP) enhanced brain stimulation reward when self-stimulation performance was high.
    • High doses of ethanol significantly reduced self-stimulation behavior.
    • The effects were dependent on ethanol concentration, stimulation intensity, and administration route.

    Conclusions:

    • Ethanol exhibits biphasic effects on brain reward, with low doses potentially potentiating and high doses inhibiting reward.
    • These findings highlight the complex interaction between ethanol and the brain's reward circuitry, influenced by dosage and administration method.

    Related Experiment Videos