[Changes in hemostasis indices after translumbar aortography]

Changes in the hemostatic system attesting to anticoagulation and antiaggregation activity of radiographic contrast substances belonging to the triiodobenzoate class were recorded in 29 patients with atherosclerosis obliterans after translumbal aortography with the use of 76% verografin in a dose of 1-1.5 ml/kg bw. The same results were obtained in experiments with 76% verografin and iodamide 380 administered to donor's plasma in vitro. Anticoagulant action was the most demonstrable in making thrombin and thrombin-heparin time longer. Antiaggregation activity was evidenced by a decrease in collagen aggregation and reduction of the second wave of aggregation of ADP and adrenaline. Administration of calcium chloride to plasma before an aggregating agent prevented aggregation disorders provoked by radiographic contrast agents.