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Related Experiment Videos

[Changes in hemostasis indices after translumbar aortography].

O S Elagin, L V Zherdeva

    Farmakologiia I Toksikologiia
    |November 1, 1983
    PubMed
    Summary

    Radiographic contrast agents, specifically triiodobenzoate, demonstrate anticoagulation and antiplatelet activity in patients with atherosclerosis obliterans. Calcium chloride administration mitigated these hemostatic system disruptions.

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    Area of Science:

    • Vascular Medicine
    • Hematology
    • Radiology

    Background:

    • Atherosclerosis obliterans affects vascular health, and diagnostic procedures like translumbal aortography utilize contrast agents.
    • The hemostatic system's role in vascular disease is critical, involving coagulation and platelet aggregation.

    Purpose of the Study:

    • To investigate the effects of triiodobenzoate radiographic contrast substances on the hemostatic system.
    • To evaluate the anticoagulation and antiplatelet activities of verografin and iodamide.

    Main Methods:

    • Observational study in 29 patients with atherosclerosis obliterans undergoing translumbal aortography with 76% verografin.
    • In vitro experiments using donor plasma with 76% verografin and iodamide 380.
    • Assessment of thrombin time, thrombin-heparin time, collagen-induced aggregation, and ADP/adrenaline-induced aggregation.

    Main Results:

    • Verografin administration induced anticoagulation and antiplatelet effects in patients and in vitro.
    • Significant prolongation of thrombin and thrombin-heparin times indicated anticoagulant activity.
    • Reduced collagen aggregation and diminished secondary aggregation waves with ADP and adrenaline demonstrated antiplatelet effects.
    • Calcium chloride pre-treatment prevented contrast agent-induced aggregation disorders.

    Conclusions:

    • Triiodobenzoate radiographic contrast agents possess significant anticoagulation and antiplatelet properties.
    • These hemostatic effects are relevant in patients with atherosclerosis obliterans undergoing aortography.
    • Calcium chloride may counteract contrast-induced hemostatic disturbances.

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