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Synthesis and biological activity of heterocyclic acyl-cholines
Abstract:
Five new heterocyclic acyl-cholines were synthetized through 1,3-dipolar cycloaddition and their adrenergic, cholinergic and histaminergic activity evaluated. The tested compounds did not show any significant activity; some of them, in particular the isoxazole derivative (X), shift the dose-response curve of norepinephrine to the left.