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Peripheral nerve abnormalities in the diabetic mutant mouse.

A K Sharma, P K Thomas, G Gabriel

    Diabetes
    |December 1, 1983
    PubMed
    Summary
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    Diabetic mice showed reduced myelinated fiber size in tibial nerves, likely due to maturational deficits rather than nerve degeneration. This finding helps understand diabetic neuropathy progression.

    Area of Science:

    • Neuroscience
    • Diabetology
    • Pathology

    Background:

    • Diabetic neuropathy is a common complication of diabetes mellitus.
    • The C57BL/Ks (db/db) mouse model exhibits genetic diabetes and associated neuropathies.

    Purpose of the Study:

    • To investigate morphometric changes in the tibial nerve of diabetic mice compared to non-diabetic controls.
    • To determine if observed fiber size reduction is due to maturational deficits or degenerative processes.

    Main Methods:

    • Morphometric analysis of tibial nerves from diabetic (db/db) and non-diabetic (m/m) mice at 6, 9, and 15 months.
    • Comparison of myelinated and unmyelinated axon parameters, including size, circularity, and associated cellular structures.

    Main Results:

    Related Experiment Videos

    • Diabetic mice exhibited reduced myelinated fiber size, affecting both axon area and myelin thickness.
    • Unmyelinated axons were unaffected; degenerative changes were minimal and similar in both groups.
    • Increased axonal glycogenosomes in diabetic nerves and reduced membrane-associated particles in myelin and unmyelinated axolemma were noted.

    Conclusions:

    • Reduced myelinated fiber diameter in diabetic mice likely represents a maturational deficit, not a primary axonopathy.
    • Age-related changes like glycogenosomes and particle reduction occur, but the primary deficit appears developmental.