Related Experiment Videos
[Color perception disorders in therapeutic glycoside serum concentrations]
Fortschritte Der Medizin
|November 17, 1983
Summary
Digitalis intoxication can cause vision problems. This study found that common maintenance therapy with digitoxin and digoxin does not significantly differ in causing color vision disturbances in female patients.
Area of Science:
- Ophthalmology
- Clinical Pharmacology
- Toxicology
Context:
- Digitalis glycosides, like digitoxin and digoxin, are widely prescribed for cardiac conditions.
- Vision deficiencies, particularly color vision disturbances, are known side effects of digitalis intoxication.
- The comparative effects of different glycosides on color vision at therapeutic levels require further investigation.
Purpose:
- To investigate the impact of digitoxin and digoxin on color vision in patients undergoing maintenance therapy.
- To determine if lipophilicity influences the degree of color vision disturbances caused by these glycosides.
- To assess if therapeutic serum concentrations of digitalis can induce color vision deficits.
Summary:
- Twenty-nine patients on digitoxin and twenty-eight on digoxin underwent the Farnsworth-Munsell-100-Hue test.
- No significant difference in total error scores was observed between patients treated with digitoxin and digoxin.
- The study suggests that color vision is influenced by digitalis therapy even at therapeutic concentrations, with no distinct difference between digitoxin and digoxin.
Impact:
- Highlights that even standard digitalis therapy can affect color vision.
- Provides evidence that digitoxin and digoxin have similar effects on color vision at therapeutic doses.
- Informs clinicians about potential visual side effects of digitalis, aiding in patient monitoring and management.