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Capillary fragility in elderly in-patients.

J Bloomer, H Morley, M J Denham

    Age and Ageing
    |May 1, 1978
    PubMed
    Summary

    Elderly patients exhibit increased capillary fragility, particularly in the non-paralyzed limb of hemiplegic individuals. This fragility is linked to systolic blood pressure and arteriosclerosis, not age itself.

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    Area of Science:

    • Gerontology
    • Vascular Biology
    • Clinical Medicine

    Background:

    • Capillary fragility is a measure of microvascular integrity.
    • Assessing capillary fragility in elderly populations is important for understanding age-related vascular changes.
    • Previous studies have not fully elucidated the factors influencing capillary fragility in healthy elderly individuals.

    Purpose of the Study:

    • To investigate capillary fragility in elderly patients, excluding those with pre-existing conditions that could affect fragility.
    • To compare capillary fragility in elderly patients with younger subjects.
    • To explore the relationship between capillary fragility, age, systolic blood pressure, and hemiplegia.

    Main Methods:

    • Capillary fragility was assessed in 110 elderly patients.
    • Exclusion criteria were applied to ensure a focus on age-related changes.
    • Capillary fragility was compared between elderly and younger subjects, and between paralyzed and non-paralyzed limbs in hemiplegic patients.

    Main Results:

    • Capillary fragility was found to be greater in elderly patients compared to younger subjects.
    • In hemiplegic patients, capillary fragility was significantly increased in the non-paralyzed arm but not the paralyzed arm.
    • Capillary fragility showed a significant correlation with systolic blood pressure but not with chronological age.

    Conclusions:

    • Increased capillary fragility in elderly patients may be associated with arteriosclerosis rather than age alone.
    • Hemiplegia may differentially affect capillary fragility in affected and unaffected limbs.
    • Systolic blood pressure is a significant factor associated with capillary fragility in the elderly.

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