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Enkephalins as immunomodulators.

N P Plotnikoff, G C Miller

    International Journal of Immunopharmacology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Methionine enkephalin and leucine enkephalin showed protective effects against L1210 murine leukemia in mice. These enkephalins also stimulated lymphocyte blastogenesis, suggesting immunomodulatory roles.

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    Area of Science:

    • Neuroimmunology
    • Immunopharmacology

    Background:

    • The role of endogenous opioid peptides in immune function is increasingly recognized.
    • Enkephalins, a class of endogenous opioid peptides, are known to influence various physiological processes.

    Purpose of the Study:

    • To investigate the protective effects of methionine enkephalin and leucine enkephalin against L1210 murine leukemia.
    • To assess the impact of these enkephalins on lymphocyte blastogenesis.

    Main Methods:

    • BDF1 mice were inoculated with L1210 murine leukemia cells.
    • Mice were treated with methionine enkephalin and leucine enkephalin.
    • Lymphocyte blastogenesis was measured in the presence of phytohemagglutinin (PHA).

    Main Results:

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    • Treatment with methionine enkephalin and leucine enkephalin significantly increased the survival rate of mice with L1210 leukemia.
    • Both enkephalins stimulated lymphocyte blastogenesis across a range of concentrations and PHA dilutions.
    • Methionine enkephalin stimulated blastogenesis at concentrations from 1 mg/ml to 10(-8) mg/ml.
    • Leucine enkephalin stimulated blastogenesis at concentrations from 1 mg/ml to 10(-10) mg/ml.

    Conclusions:

    • Enkephalins exhibit protective effects against murine leukemia and act as direct immunostimulants.
    • Endogenous enkephalins may play a crucial neuroendocrine role, bridging the central nervous system and the immune system.
    • These findings support the potential therapeutic application of enkephalins in immunomodulation.