Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Plasma phentermine levels, weight loss and side-effects.

A Douglas, J G Douglas, C E Robertson

International Journal of Obesity

|January 1, 1983

Summary

Phentermine resinate demonstrated moderate weight loss in women with refractory obesity, but individual responses and side effects were unpredictable. Patient outcomes varied, with plasma drug concentrations not correlating to weight loss effectiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Collapse of Nuclear Collectivity along the N=Z Line.

Physical review letters·2026

Same author

"Turning up the heat": role of neurotrophic batokines in the postnatal maturation and remodeling of brown adipose tissue in deer mice.

American journal of physiology. Endocrinology and metabolism·2023

Same author

Impact of COVID-19 on national surveillance of norovirus in England and potential risk of increased disease activity in 2021.

The Journal of hospital infection·2021

Same author

Diabetes incidence in a high-risk UK population at 7 years: linkage of the Prevention of Diabetes and Obesity in South Asians (PODOSA) trial to the Scottish Diabetes Register.

Diabetic medicine : a journal of the British Diabetic Association·2020

Same author

Ethnic variations in falls and road traffic injuries resulting in hospitalisation or death in Scotland: the Scottish Health and Ethnicity Linkage Study.

Public health·2020

Same author

An outbreak of Shiga Toxin-producing Escherichia coli O157:H7 associated with contaminated salad leaves: epidemiological, genomic and food trace back investigations - CORRIGENDUM.

Epidemiology and infection·2018

Area of Science:

Pharmacology
Obesity Research
Clinical Medicine

Background:

Refractory obesity presents a significant challenge in clinical practice.
Pharmacological interventions are often necessary for managing severe obesity.
Phentermine resinate is a commonly prescribed appetite suppressant.

Purpose of the Study:

To evaluate the efficacy and safety of phentermine resinate in women with refractory obesity.
To investigate the relationship between plasma phentermine concentrations and weight loss.
To explore factors influencing individual patient response to phentermine.

Main Methods:

A study involving 50 women with refractory obesity receiving phentermine resinate.
Monitoring for side effects and weight loss over a 20-week period.

Related Experiment Videos

Measuring plasma phentermine concentrations and correlating them with clinical outcomes.

Main Results:

Mean weight loss of 6.4 kg in 34 completers; 9 patients lost ≥10 kg.
Reported side effects included headaches, hypertension, and irritability.
Plasma phentermine levels did not correlate with obesity severity, appetite suppression, or weight loss.

Conclusions:

Phentermine resinate can lead to significant weight loss in some individuals with refractory obesity.
Individual patient response to phentermine is unpredictable and not solely dependent on plasma drug concentrations.
Higher dosages may not improve outcomes for patients with a poor initial response.