Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dermal collagen distribution. A histochemical and ultrastructural study.

L C Junqueira, G S Montes, J E Martins

    Histochemistry
    |January 1, 1983
    PubMed
    Summary

    This study reveals that collagen type III fibers are mainly in the upper dermis, while collagen type I fibers dominate the deeper skin layers. These findings clarify collagen distribution in mammalian skin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence of macrophage modulation in the mouse pubic symphysis remodeling during the end of first pregnancy and postpartum.

    Scientific reports·2020
    Same author

    Reduced LRP6 expression and increase in the interaction of GSK3β with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea.

    The Journal of nutritional biochemistry·2015
    Same author

    [Effect of subglottic air insufflation on subglottic pressure during swallowing].

    Medicina intensiva·2013
    Same author

    Cellulitis lesions in broiler chickens are induced by Escherichia coli Vacuolating Factor (ECVF).

    Veterinary microbiology·2012
    Same author

    Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways.

    Journal of molecular and cellular cardiology·2011
    Same author

    The influence of low oxygen on macrophage response to Leishmania infection.

    Scandinavian journal of immunology·2011

    Area of Science:

    • Dermatology
    • Histology
    • Biochemistry

    Background:

    • Collagen is a crucial structural protein in mammalian skin.
    • Different collagen types have distinct roles and distributions within skin layers.
    • Understanding collagen localization is vital for dermatology and regenerative medicine.

    Purpose of the Study:

    • To investigate the specific localization and characteristics of collagen types I and III in mammalian skin.
    • To correlate histological and ultrastructural findings with known collagen types.

    Main Methods:

    • Utilized silver impregnation for reticulin fibers.
    • Employed the Picrosirius-polarization method for collagen identification.
    • Conducted transmission electron microscopy on skin biopsy specimens from five mammalian species, including humans.

    Related Experiment Videos

    Main Results:

    • Argyrophilic reticulin fibers in the adventitial dermis exhibited characteristics of collagen type III.
    • Coarser collagen fibers in deeper skin layers showed ultrastructural and histochemical features of collagen type I.
    • Findings align with previous biochemical and immunohistologic studies.

    Conclusions:

    • Collagen type III is predominantly found in the upper dermis.
    • Collagen type I is the main collagen type in the deeper dermal layers.
    • This distribution pattern of collagen types I and III is conserved across studied mammalian species.