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[Changes in plasma prolactin levels after gynecologic surgery].

D Aravantinos, V Tzingounis

    Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
    |January 1, 1983
    PubMed
    Summary

    Total abdominal hysterectomy (TAH) and minor surgery temporarily increase serum prolactin (PRL) levels. These hormonal changes return to normal within six weeks, indicating operative stress as the likely cause.

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    Area of Science:

    • Reproductive Endocrinology
    • Surgical Physiology

    Background:

    • Serum prolactin (PRL) levels can be influenced by various physiological and surgical factors.
    • Understanding hormonal responses to surgical procedures is crucial for patient management.

    Purpose of the Study:

    • To investigate the effect of total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH) on serum prolactin (PRL) levels.
    • To compare PRL level changes in women undergoing TAH versus minor surgery.

    Main Methods:

    • Serum PRL levels were measured in 17 women of reproductive age before and after TAH.
    • A control group of 15 women who underwent minor surgery was included for comparison.
    • Hormonal levels were assessed 24 hours and six weeks post-surgery.

    Main Results:

    • A significant increase in serum PRL levels was observed 24 hours after both TAH and minor surgery.
    • Serum PRL levels returned to pre-operative baseline levels in all participants by six weeks post-operation.

    Conclusions:

    • The transient rise in serum prolactin following surgery is attributed to operative stress.
    • Surgical stress, rather than the specific procedure (TAH vs. minor surgery), appears to be the primary driver of acute PRL elevation.

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