Tyrosine's vasoactive effect in the dog shock model depends on the animal's starting blood pressure

We examined the effect of tyrosine (10-200 mg/kg given intravenously) or placebo on blood pressure (BP) in dogs made hypotensive (systolic BP = 50 mm Hg) by bleeding one hour previously. Animals which, prior to induction of hypotension, had been normotensive (mean arterial pressures, [MAP] less than or equal to 145 mm Hg) subsequently exhibited a dose-related increase in BP after tyrosine administration. In contrast, dogs which had been hypertensive prior to bleeding exhibited a fall in BP after tyrosine. These observations indicated that prior cardiovascular status may be an important factor influencing responses to exogenous tyrosine, and to endogenous catecholamines produced from the tyrosine.