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Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion.
Journal of Toxicology. Clinical Toxicology
|June 1, 1983
Summary
This case study shows that hemoperfusion effectively treated a life-threatening primidone overdose. The procedure rapidly improved the patient's critical condition, including coma and acute kidney injury.
Area of Science:
- Clinical Toxicology
- Nephrology
- Pharmacology
Background:
- Primidone overdose can lead to severe toxicity, including central nervous system depression, hypotension, and acute kidney injury.
- Crystalluria is a potential complication of primidone overdose, indicating renal impairment.
Observation:
- A patient presented with coma, hypotension, and acute renal failure with crystalluria following a massive primidone overdose.
- Initial plasma primidone concentration was critically high at 209 mg/l.
Findings:
- Hemoperfusion was initiated due to the patient's severe clinical status and high primidone levels.
- Hemoperfusion demonstrated significant drug clearance, effectively reducing plasma primidone concentrations.
- The patient exhibited remarkable clinical improvement following the hemoperfusion procedure.
Implications:
- Hemoperfusion is a potentially life-saving intervention for severe primidone poisoning.
- This case highlights the efficacy of hemoperfusion in managing acute drug-induced renal failure and toxicity.
- Early consideration of extracorporeal techniques like hemoperfusion is crucial in critical overdose scenarios.