Rhabdomyolysis and acute myoglobinuric renal failure associated with methadone intoxication

A case of methadone intoxication is presented. The clinical manifestations were rhabdomyolysis and myoglobinuric acute renal failure. In most cases of drug intoxication, these features occur secondary to previous coma or prolonged immobilization. Since our patient was neither comatose nor immobilized, we suggest that a toxic action of methadone was responsible for rhabdomyolysis.