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[Clinical evaluation of an ampicillin suppository (KS-R1) in pediatrics]
Insights
Ampicillin suppositories (KS-R1) achieve therapeutic blood levels comparable to injections, offering a superior option for pediatric bacterial infections.
Area of Science:
- Pharmacology
- Microbiology
- Pediatrics
Context:
- Bacterial infections pose a significant threat in pediatric care.
- Effective antibiotic delivery is crucial for successful treatment outcomes.
- Ampicillin is a widely used antibiotic for various bacterial infections.
Purpose:
- To evaluate the pharmacokinetic and clinical efficacy of a novel ampicillin suppository formulation (KS-R1).
- To compare the blood levels of ampicillin achieved with KS-R1 to other administration routes.
- To assess the therapeutic effectiveness of KS-R1 in treating pediatric bacterial infections.
Summary:
- Ampicillin suppositories (KS-R1) demonstrated peak blood concentrations of 300 ng/ml at 60 minutes post-administration (1 mg/kg/day).
- Achieved blood levels were comparable to intramuscular injection and superior to oral ampicillin.
- KS-R1 exhibited a clinical effective rate exceeding 95% (excellent and good) and an overall efficacy rate over 95% including bacteriological effects.
Impact:
- KS-R1 presents a valuable and effective alternative for ampicillin administration in pediatric patients.
- The suppository formulation offers a potentially more convenient and effective route for treating pediatric bacterial infections.
- This research supports the utility of KS-R1 in improving treatment adherence and outcomes in pediatric infectious diseases.
Abstract:
Blood level of ampicillin (ABPC) after the administration of ABPC suppository (KS-R1) reached a peak in 15 approximately 60 minutes with the level of 300 ng/ml at a dose of 1 mg/kg/day. This level was almost the same as that after the intramuscular injection of ABPC, and higher than that after the oral administration of ABPC which were reported. The clinical effective rate (excellent and good) of KS-R1 was more the 95%, and the overall effective rate including bacteriological effect was more than 95%. It is concluded that KS-R1 is a useful drug for the treatment of bacterial infections in pediatric field.