[Experimental and clinical studies of latamoxef in intestinal surgery]

After the intravenous administration of 1.0 g of latamoxef (LMOX), the concentration of LMOX were determined in normal intestinal tissue and serum of 17 patients underwent surgery for intestinal problems, and the results obtained were as follows. At 60 approximately 150 minutes after administration, the levels of LMOX were 37.5 approximately 26.3 micrograms/ml in serum and 14.8 approximately 10.5 micrograms/g in normal intestinal tissues. This values were enough to inhibit the growth of Gram-negative bacteria caused for some postoperative wound infections. For intravenous administration of 1.0 g of LMOX just before operation, no wound infection was observed in 13 patients with large intestinal cancer and 4 patients with benign intestinal disease.