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Evolutionary changes in the information content of polypeptides.

K Matsuno

    Journal of Theoretical Biology
    |November 21, 1983
    PubMed
    Summary

    Early thermal proteins, formed by self-sequencing amino acids, are potential evolutionary precursors. Their development shows increasing autocatalysis and a shift in information translation, aligning with protein evolution theories.

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    Area of Science:

    • Biochemistry
    • Evolutionary Biology
    • Origin of Life Studies

    Background:

    • Contemporary proteins are complex polymers essential for life.
    • The origin of protein synthesis and evolution remains a key question in abiogenesis.
    • Self-sequencing of amino acids offers a potential abiotic pathway to polypeptide formation.

    Purpose of the Study:

    • To evaluate thermal proteins from self-sequencing amino acids as candidates for early protein precursors.
    • To explore the dynamics of polypeptide production and information content evolution.
    • To investigate the role of autocatalysis and material flow in early molecular evolution.

    Main Methods:

    • Theoretical analysis of polypeptide formation through self-sequencing.
    • Modeling of information content changes in evolving polypeptide ensembles.
    • Examination of autocatalysis dynamics and material flow equilibration principles.
    • Investigating the proposed shift in information translation from polypeptide-to-polynucleotide to polynucleotide-to-polypeptide.

    Main Results:

    • Self-sequencing amino acids can produce thermal proteins meeting precursor criteria.
    • Polypeptide information content evolves endogenously, driven by changes in production mechanisms.
    • Autocatalysis increases over time, reducing the number of polymers needed for synthesis.
    • Material flow equilibration governs system dynamics, ensuring continuity in open systems.
    • Incorporation of polynucleotides marks a shift in information translation direction.

    Conclusions:

    • Thermal proteins are plausible evolutionary precursors to contemporary proteins.
    • The proposed model explains the transition from abiotic self-sequencing to genetically encoded protein synthesis.
    • The dynamics described are consistent with a materialist view of early molecular evolution and the origin of the genetic code.

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