Nitroblue tetrazolium test in patients with neoplasma during surgical treatment

In 20 patients with alimentary tract neoplasma, nitroblue tetrazolium test (NBT) with resting and stimulated granulocytes was done using Park's et al. [14] method. NBT test was determined in peripheral blood before surgical intervention, in blood from vessel draining of tumor before its excision and in peripheral blood 2-3 weeks after excision of tumor. In parallel experiments the NBT test was estimated in peripheral blood of 21 healthy individuals. We have shown that NBT dye reduction was evidently diminished in patients with cancer disease especially in blood samples from vein draining of tumor both in resting and stimulated granulocytes. The excision of tumor caused improvement of NBT dye reduction. The importance of determination of NBT test in patients with cancer disease is briefly discussed.