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Calcitonin in thyroidectomized patients.

O Silva, L A Wisneski, J Cyrus

    The American Journal of the Medical Sciences
    |March 1, 1978
    PubMed
    Summary
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    Hypothyroid patients lacking a thyroid gland still had measurable calcitonin. This suggests that tissues outside the thyroid may produce this hormone, impacting human calcitonin research.

    Area of Science:

    • Endocrinology
    • Molecular Biology

    Background:

    • Calcitonin is a hormone primarily associated with the thyroid gland.
    • Thyroidectomy, the surgical removal of the thyroid, is a common treatment for various thyroid conditions.

    Purpose of the Study:

    • To investigate the presence of calcitonin in patients after thyroidectomy.
    • To explore the possibility of extrathyroidal calcitonin secretion.

    Main Methods:

    • Measurement of immunoreactive calcitonin in serum and urine samples.
    • Analysis of samples from hypothyroid patients who underwent total or near-total thyroidectomy.

    Main Results:

    • Detectable levels of immunoreactive calcitonin were found in both serum and urine of post-thyroidectomy hypothyroid patients.

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  • The presence of calcitonin indicates a source independent of the thyroid gland.

    • Conclusions:

    • Human calcitonin can be secreted by extrathyroidal tissues.
    • These findings necessitate a re-evaluation of calcitonin's physiological origins and potential roles.