Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation in migraine.

G D Lord, J W Duckworth, J A Charlesworth

    Lancet (London, England)
    |April 9, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This study suggests complement activation plays a role in migraine headaches. Researchers observed reduced complement components during attacks, indicating a potential link to migraine phenomena.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluating the use of taxonomy in the IUCN Red List.

    Conservation biology : the journal of the Society for Conservation Biology·2026
    Same author

    The difference conservation makes to extinction risk of the world's ungulates.

    Conservation biology : the journal of the Society for Conservation Biology·2015
    Same author

    The impact of conservation on the status of the world's vertebrates.

    Science (New York, N.Y.)·2010
    Same author

    Modelling the species distribution of flat-headed cats (Prionailurus planiceps), an endangered South-East Asian small felid.

    PloS one·2010
    Same author

    The status of the world's land and marine mammals: diversity, threat, and knowledge.

    Science (New York, N.Y.)·2008
    Same author

    Sensory nerve excitability and neuropathy in end stage kidney disease.

    Journal of neurology, neurosurgery, and psychiatry·2006
    Same journal

    Convergence of metabolic risk in obesity and normal BMI: does risk disappear?

    Lancet (London, England)·2026
    Same journal

    Metabolic traits in obesity and normal BMI in industrialised countries: a multi-country analysis of national population-based studies.

    Lancet (London, England)·2026
    Same journal

    Safety and efficacy of mRNA vaccines: a mechanistic and public health perspective.

    Lancet (London, England)·2026
    Same journal

    The US Ebola response and the future of global health leadership.

    Lancet (London, England)·2026
    Same journal

    Daniel Mason: a tale of change.

    Lancet (London, England)·2026
    Same journal

    The 2026 Wakley-Wu Lien Teh Prize Essay: why medicine, and why stay?

    Lancet (London, England)·2026
    See all related articles

    Area of Science:

    • Neurology
    • Immunology

    Background:

    • Migraine is a common neurological disorder with complex pathophysiology.
    • Previous research has suggested various mechanisms, but the exact cause remains unclear.

    Purpose of the Study:

    • To investigate the potential role of complement activation in migraine headaches.
    • To determine if complement component levels or breakdown products correlate with migraine attacks.

    Main Methods:

    • Serum complement component levels (C4, C5) were measured in nine migraine patients during and outside of headache episodes.
    • Complement C3 breakdown products were analyzed in the plasma of 31 headache-free patients.

    Main Results:

    • Significant reductions in complement components C4 and C5 were observed during migraine headaches.

    Related Experiment Videos

  • C3 breakdown products were detected in three patients who later experienced a migraine attack, but not in those who remained headache-free.

    • Conclusions:

    • These findings provide evidence for complement activation during migraine attacks.
    • Complement activation may be a contributing factor to the symptoms and phenomena associated with migraine headaches.