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Value of profiling liver function in the elderly.

J R Lubin, J A Coles, B A Millward

    Postgraduate Medical Journal
    |December 1, 1983
    PubMed
    Summary
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    Routine liver function tests in geriatric patients revealed abnormalities in 27%, aiding diagnosis in half of those cases. Unindicated profiling identified occult liver issues in 6% of patients, diagnosing osteomalacia and gallstones.

    Area of Science:

    • Geriatric Medicine
    • Clinical Biochemistry
    • Diagnostic Testing

    Background:

    • Liver function tests (LFTs) are commonly used in clinical practice.
    • The utility of routine LFTs in asymptomatic geriatric populations requires evaluation.
    • Identifying liver function abnormalities can impact patient management and diagnosis.

    Purpose of the Study:

    • To prospectively assess the clinical value of three routine liver function tests.
    • To determine the yield of liver function profiling in geriatric patients without specific indications.

    Main Methods:

    • Prospective study involving 523 geriatric patients.
    • Measurement of three routine liver function tests.
    • Analysis of clinical helpfulness of abnormal test results.

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    Main Results:

    • Abnormalities in liver function tests were detected in 27% of patients.
    • Clinical information was significantly improved in 50% of patients with abnormal results.
    • Unindicated liver function profiling identified abnormalities in 17% of patients, with clinical importance in 6% of the total cohort.
    • Key diagnoses included unsuspected osteomalacia and gallstone disease.

    Conclusions:

    • Routine liver function testing can be valuable in geriatric patients, particularly when abnormalities are clinically relevant.
    • Liver function profiling without a clear clinical indication has a lower yield but can uncover significant diagnoses.
    • The findings support a judicious approach to ordering liver function tests in the elderly.