Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal involvement in systemic amyloidosis.

M Browning, R Banks, C Tribe

    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
    |January 1, 1983
    PubMed
    Summary

    Systemic amyloidosis frequently impacts kidneys, leading to renal failure. Glomerular amyloid infiltration in AA amyloidosis correlates with kidney function decline and proteinuria, but end-stage disease can be managed with CAPD.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prehabilitation of Patients With Oesophageal Malignancy Undergoing Peri-Operative Treatment (Pre-EMPT): Outcomes From a Prospective Controlled Trial.

    Journal of surgical oncology·2025
    Same author

    Modeling Hydrogen Markets: Energy System Model Development Status and Decarbonization Scenario Results.

    Energy and climate change·2025
    Same author

    The promise of layer-specific neuroimaging for testing predictive coding theories of psychosis.

    Schizophrenia research·2020
    Same author

    Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

    Living reviews in relativity·2020
    Same author

    GW190521: A Binary Black Hole Merger with a Total Mass of 150  M_{⊙}.

    Physical review letters·2020
    Same author

    Characterization of transient noise in Advanced LIGO relevant to gravitational wave signal GW150914.

    Classical and quantum gravity·2020

    Area of Science:

    • Nephrology
    • Internal Medicine
    • Pathology

    Background:

    • Systemic amyloidosis, a group of diseases characterized by extracellular deposition of insoluble protein fibrils, commonly affects the kidneys.
    • Renal involvement is a significant presenting feature and a major determinant of prognosis in both AA and AL amyloidosis.
    • Understanding the relationship between amyloid deposition and renal function is crucial for patient management.

    Purpose of the Study:

    • To investigate the prevalence and impact of renal involvement in systemic amyloidosis.
    • To determine the correlation between glomerular amyloid infiltration and markers of renal dysfunction and proteinuria in AA amyloidosis.
    • To assess the feasibility of continuous ambulatory peritoneal dialysis (CAPD) in patients with end-stage renal amyloidosis.

    Main Methods:

    Related Experiment Videos

    • Retrospective analysis of 124 patients with systemic amyloidosis (AA and AL types).
    • Review of renal biopsies from 23 patients with AA amyloidosis, including quantitative assessment of glomerular amyloid infiltration.
    • Correlation analysis between amyloid infiltration, urinary protein excretion, serum creatinine, and renal function.
    • Evaluation of CAPD outcomes in four patients with end-stage renal amyloidosis.

    Main Results:

    • Renal involvement was the primary presentation in 68% of AA and 42% of AL amyloidosis patients.
    • Renal failure contributed to mortality in 72% of AA and 33% of AL amyloidosis patients.
    • In AA amyloidosis, glomerular amyloid infiltration correlated with proteinuria and serum creatinine levels; changes in amyloid correlated with changes in renal function.

    Conclusions:

    • Renal involvement is a critical factor in the presentation and outcome of systemic amyloidosis.
    • Glomerular amyloid burden directly impacts renal function and proteinuria in AA amyloidosis.
    • CAPD offers a viable management option for patients with end-stage renal amyloidosis.