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Cortical infarction in rabbits with serum sickness following Cyclosporin A therapy
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
|January 1, 1983
Abstract:
Rabbits given acute serum sickness (ASS) and treated with Cyclosporin A (CyA) developed glomerular capillary thrombosis and cortical infarction. These lesions were associated with severe endothelial injury and platelet-fibrin-leucocyte thrombi. They were not seen in untreated rabbits with ASS, nor in normal rabbits given CyA alone in equivalent doses. A similar renal lesion has been reported in patients receiving CyA following bone marrow transplantation.