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Is renal glycosuria a benign condition?

S De Marchi, E Cecchin, A Basile

    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
    |January 1, 1983
    PubMed
    Summary

    This study links inherited renal glycosuria to an autosomal dominant gene on chromosome six, closely associated with the HLA complex. Affected individuals show multiple autoantibodies, suggesting it

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    Area of Science:

    • Genetics
    • Immunology
    • Nephrology

    Background:

    • Renal glycosuria is traditionally considered a benign inherited condition.
    • The genetic and immunological underpinnings of type A renal glycosuria require further elucidation.

    Purpose of the Study:

    • To investigate the genetic basis of type A renal glycosuria within affected families.
    • To explore the association between HLA typing and autoantibody production in renal glycosuria patients.

    Main Methods:

    • Human Leukocyte Antigen (HLA) typing was performed on five families with type A renal glycosuria.
    • A comprehensive panel of autoantibodies was assessed in affected family members.

    Main Results:

    • HLA typing confirmed an autosomal dominant inheritance pattern for renal glycosuria, linked to the HLA complex on chromosome six.

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  • Affected individuals consistently exhibited elevated autoantibodies against various antigens, including nuclear, DNA, smooth muscle, mitochondria, liver, and thyroid components, as well as renal tubule brush border.

    • Conclusions:

    • Type A renal glycosuria is an HLA-linked complex genetic disorder, not merely a benign condition.
    • Increased susceptibility to multiple autoantibody production is a key feature, necessitating a re-evaluation of its classification.