The effect of naloxone on intragastric ethanol self-administration

The acute effect of 1.25 and 2.50 mg/kg naloxone was tested in a group of male Wistar rats readily self-administering 10% w/v ethanol intragastrically following 12 days of forced ethanol intoxication. Compared to saline pretreatment, naloxone did not alter 24 hr intakes of food, water or ethanol. However, both does strongly and significantly inhibited lever pressing for ethanol during 2 hr following pretreatment. The results indicate that naloxones's inhibition of ethanol intake does have a transient postabsorptive component, although this component is unlikely to be specific to ethanol.