[Interaction of a natural modifier of lethal effect of radiation with HeLa cells]

Polypeptide 14C-aspartyl glutamate, a chemical analogue of a natural modified of a lethal effect of radiation, has been synthesized. The modifier was shown to react readily with nucleic acids and proteins of non-irradiated cells: the reaction was considerably enhanced when the modifier was administered simultaneously with radiation of cells. As is known from the literature, a molar concentration of the incorporated polypeptide is considerably lower than the intracellular molar concentration of an active radiosensitizer, BUdr, which produces an effect on mammalian cells comparable with that of polypeptide.