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Related Experiment Videos

Extrapyramidal side effects with lithium treatment.

J Kane, A Rifkin, F Quitkin

    The American Journal of Psychiatry
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Lithium carbonate can cause extrapyramidal side effects like cogwheeling in some patients. Neurological exams of 38 patients confirmed cogwheeling in 2 individuals, supporting previous findings in lithium-treated individuals.

    Area of Science:

    • Neurology
    • Psychiatry

    Background:

    • Lithium carbonate is a common mood stabilizer.
    • Extrapyramidal side effects (EPS) are known potential adverse effects of certain medications.

    Purpose of the Study:

    • To investigate the occurrence of extrapyramidal side effects, specifically cogwheeling, in patients treated with lithium carbonate.
    • To confirm previous reports on lithium-induced cogwheeling.

    Main Methods:

    • Neurological examination of 38 patients who received lithium carbonate for 3 months to 5 years.
    • Exclusion of patients who received neuroleptics within 3 months prior to examination.

    Main Results:

    • Definite cogwheeling was observed in 2 out of 38 patients.
    • The findings align with and support prior research on lithium carbonate's side effects.

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    Conclusions:

    • Lithium carbonate treatment is associated with a risk of developing extrapyramidal side effects such as cogwheeling.
    • Regular neurological monitoring may be warranted for patients on long-term lithium therapy.