Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebrospinal fluid norepinephrine in affective illness.

R M Post, C R Lake, D C Jimerson

    The American Journal of Psychiatry
    |August 1, 1978
    PubMed
    Summary

    Central norepinephrine levels were higher in manic patients compared to depressed patients. These findings suggest norepinephrine metabolism changes are linked to mood and motor activity alterations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effects of type 1 diabetes on cerebral white matter.

    Diabetologia·2007
    Same author

    Co-morbidity and disorder-related distress and impairment in purging disorder.

    Psychological medicine·2007
    Same author

    Laboratory screening for electrolyte abnormalities and anemia in bulimia nervosa: a controlled study.

    The International journal of eating disorders·2001
    Same author

    Decreased serum leptin in bulimia nervosa.

    The Journal of clinical endocrinology and metabolism·2001
    Same author

    Serotonin function following remission from bulimia nervosa.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2000
    Same author

    Salivary gland enlargement and elevated serum amylase in bulimia nervosa.

    Biological psychiatry·1999

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Biochemistry

    Background:

    • Norepinephrine is a key neurotransmitter implicated in mood regulation.
    • Previous research suggests altered norepinephrine metabolism in psychiatric disorders.

    Purpose of the Study:

    • To investigate cerebrospinal fluid (CSF) norepinephrine concentrations in patients with mania, depression, and neurological controls.
    • To examine the effect of probenecid, a substance that blocks organic acid transport, on CSF norepinephrine levels.

    Main Methods:

    • Measurement of CSF norepinephrine concentrations in three patient groups: manic, depressive, and neurological controls.
    • Administration of probenecid to assess its impact on norepinephrine levels.
    • Comparison of baseline and probenecid-induced norepinephrine values across groups.

    Related Experiment Videos

    Main Results:

    • Significantly higher baseline and probenecid-induced CSF norepinephrine levels were observed in manic patients compared to depressed patients.
    • Depressed patients did not show significant differences in CSF norepinephrine levels compared to neurological controls.
    • Depressed patients with high anxiety exhibited higher CSF norepinephrine levels than those with low anxiety.

    Conclusions:

    • Central norepinephrine metabolism appears to be altered in manic and depressed patients.
    • Changes in mood and motor activity may correlate with alterations in central norepinephrine metabolism.
    • Norepinephrine may play a role in the pathophysiology of mood disorders, particularly in relation to anxiety levels in depression.