Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxythioquinox-induced hepatomegaly.

G Carrera, C Cambon-Gros, S Mitjavila

    Toxicology Letters
    |October 1, 1983
    PubMed
    Summary

    Oxythioquinox exposure caused severe liver steatosis and significant increases in liver lipids. This toxicity varied with how well the compound was dissolved in its administration vehicle.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Paraquat potentiates iron-induced microsomal lipid peroxidation: modulation by the diet lipid composition.

    Redox report : communications in free radical research·2016
    Same author

    [Palivizumab for respiratory syncytial virus disease].

    Minerva pediatrica·2013
    Same author

    Cadmium accumulation and cytotoxicity in rat hepatocytes co-cultured with a liver epithelial cell line.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    B lymphocyte subsets and their functional activity in the early months of life.

    International journal of immunopathology and pharmacology·2010
    Same author

    Reparation of a severe case of aplasia cutis congenita with engineered skin.

    Biology of the neonate·2001
    Same author

    The impact of PTSD on treatment adherence in persons with HIV infection.

    General hospital psychiatry·2001

    Area of Science:

    • Toxicology
    • Biochemistry
    • Animal Nutrition

    Background:

    • Oxythioquinox is an acaricide/insecticide used in agriculture.
    • Understanding its toxicological profile is crucial for risk assessment.

    Purpose of the Study:

    • To investigate the toxic effects of Oxythioquinox on liver metabolism.
    • To evaluate the influence of administration vehicle on Oxythioquinox toxicity.

    Main Methods:

    • Rats were administered Oxythioquinox in dietary lipids at 400 mg/kg for 21 days.
    • Liver tissues were analyzed for hypertrophy, steatosis, and lipid content (triglycerides, phospholipids, cholesterol).

    Main Results:

    • Oxythioquinox administration induced severe liver steatosis and significant liver hypertrophy.
    • Liver triglycerides increased 40-fold, cholesterol 7-fold, and phospholipids 2-fold.
    • Toxicity was dependent on the compound's solubilization in the administration vehicle.

    Conclusions:

    • Oxythioquinox significantly disrupts hepatic lipid metabolism, leading to severe steatosis.
    • The formulation and solubilization of Oxythioquinox are critical factors influencing its toxicity.

    Related Experiment Videos