Related Experiment Video

Updated: Aug 15, 2026

Primary Endodermal Epithelial Cell Culture from the Yolk Sac Membrane of Japanese Quail Embryos
11:53

Primary Endodermal Epithelial Cell Culture from the Yolk Sac Membrane of Japanese Quail Embryos

Published on: March 10, 2016

[Intestinal dipeptidases and their regulation in chicks of different ages]

I L Tarvid, R I Kushak

    Zhurnal Evoliutsionnoi Biokhimii I Fiziologii
    |November 1, 1983
    PubMed

    Insights

    During chick development, membrane glycyl-valine dipeptidase activity decreases, particularly in the distal small intestine. Intracellular enzyme activity remains stable, unaffected by age or location.

    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Enzymology

    Context:

    • Investigates the postnatal development of glycyl-valine dipeptidase in chick small intestines.
    • Focuses on both membrane-bound and intracellular enzyme forms.
    • Examines changes from day 1 to day 40 of life.

    Purpose:

    • To characterize age-related alterations in the catalytic activity and regulatory properties of glycyl-valine dipeptidase.
    • To determine the spatial distribution and developmental trends of these enzymes along the chick small intestine.
    • To assess the influence of age on enzyme response to specific modifiers.

    Summary:

    • Membrane glycyl-valine dipeptidase activity significantly declines during postnatal development, exhibiting a proximodistal gradient with peak activity distally.
    • The regulatory effects of modifiers like tributyrine, sucrose, and L-methionine are age-dependent.
    • Intracellular glycyl-valine dipeptidase shows consistent activity and regulatory properties throughout postnatal development and along the intestine.

    Impact:

    • Provides insights into the developmental regulation of peptide digestion in chicks.
    • Highlights differential maturation of membrane-associated versus intracellular enzymes.
    • Suggests age-specific nutritional or therapeutic strategies may be needed for optimal peptide absorption.

    More Related Videos

    Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis07:05

    Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

    Published on: May 12, 2019

    Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids08:15

    Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

    Published on: November 15, 2019

    Related Concept Videos

    Hormonal Regulation01:40

    Hormonal Regulation

    Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
    Cell Specific Gene Expression01:58

    Cell Specific Gene Expression

    Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
    Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

    Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

    The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
    Insulin and C-peptide are co-secreted in...
    Dipeptidyl Peptidase 4 Inhibitors01:23

    Dipeptidyl Peptidase 4 Inhibitors

    Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...