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Related Experiment Videos

Organic acids or urine in multiple sclerosis.

G Steen, L Ransnäs

    Acta Neurologica Scandinavica
    |October 1, 1983
    PubMed
    Summary

    Multiple Sclerosis (MS) patients showed altered urinary excretion of specific organic acids, notably elevated 2-hydroxy-2-methyl-3-butenoic acid. Some MS cases also exhibited increased 3-methylglutaconic acid, suggesting potential isoprenoid biosynthesis pathway defects.

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    Area of Science:

    • Biochemistry
    • Neuroscience
    • Metabolomics

    Background:

    • Multiple Sclerosis (MS) is a chronic neurological disease with complex etiology.
    • Metabolic alterations, including changes in organic acid excretion, are increasingly investigated in MS pathogenesis.

    Purpose of the Study:

    • To investigate differences in urinary organic acid profiles between individuals with Multiple Sclerosis and healthy controls.
    • To explore potential links between specific organic acid elevations and MS, particularly focusing on isoprenoid metabolism.

    Main Methods:

    • Analyzed urinary organic acid concentrations, normalized to creatinine, in 509 MS cases and 50 controls.
    • Utilized mass spectrometry for organic acid quantification.
    • Administered deuterium-labeled acetate to a patient with elevated 3-methylglutaconic acid to trace metabolic pathways.

    Main Results:

    • No significant differences in many organic acids, but a two-fold increase in 2-hydroxy-2-methyl-3-butenoic acid in MS patients.
    • Elevated 3-methylglutaconic acid observed in 8 MS cases, with moderate elevations also in 2 controls.
    • Increased excretion of adipic acid, lactic acid, succinic acid, aconitic acid, and 3-methyladipic acid noted in MS patients.

    Conclusions:

    • Specific organic acid elevations in MS patients, particularly 2-hydroxy-2-methyl-3-butenoic acid and 3-methylglutaconic acid, warrant further investigation.
    • Findings suggest a potential role for altered isoprenoid biosynthesis pathways in Multiple Sclerosis.
    • Metabolomic profiling of organic acids may offer insights into MS pathophysiology and potential biomarkers.

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