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External pressure--blood flow relations during limb compression in man.

Acta Physiologica Scandinavica

|November 1, 1983

Summary

Increased tissue pressure triggers vasodilation in muscles, but blood flow stops when pressure equals diastolic blood pressure. Distending vessels restores flow, indicating arterial collapse causes cessation.

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Area of Science:

Physiology
Vascular Biology
Biomedical Engineering

Background:

Tissue pressure significantly influences local blood flow.
Understanding autoregulation mechanisms is crucial for managing circulatory health.

Purpose of the Study:

To investigate the impact of elevated tissue pressure on subcutaneous and skeletal muscle blood flow.
To explore the mechanisms of blood flow cessation and restoration under compression.

Main Methods:

Utilized the 133Xe washout technique to measure blood flow in 8 healthy humans.
Applied graduated compression cuffs to alter tissue pressure and induce vasodilation/vasoparalysis.
Manipulated proximal cuff pressure to distend compressed vessels.

Main Results:

Increased tissue pressure stimulated arteriolar vasodilation (autoregulation) in both muscle types.
Autoregulation was partially opposed by increased postcapillary vascular resistance.
Blood flow ceased when compression pressure reached local diastolic blood pressure.
Restoration of blood flow occurred upon distending compressed vessels.

Conclusions:

Arterial-arteriolar collapse during diastole is the primary cause of blood flow cessation in compressed tissues.
The systolic blood volume is insufficient to overcome distal precapillary vessel collapse.
Autoregulation plays a role, but mechanical compression effects are dominant at critical pressure levels.

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