Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

750
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
750
Genetics of Speciation02:16

Genetics of Speciation

21.8K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.8K
What is Population Genetics?01:25

What is Population Genetics?

64.9K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.9K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.3K
Overview
80.3K
Quantitative Aspects of Drug-Receptor Interaction01:30

Quantitative Aspects of Drug-Receptor Interaction

1.8K
The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
1.8K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

THE LANSING EFFECT REVISITED. II.-CUMULATIVE AND SPONTANEOUSLY REVERSIBLE PARENTAL AGE EFFECTS ON FECUNDITY IN DROSOPHILA MELANOGASTER.

Evolution; international journal of organic evolution·2017
Same author

Spontaneous locomotor activity of Drosophila melanogaster flies at various gravity levels (0 g, 1 g, 1.8 g) during parabolic flights.

Behavioural processes·2014
Same author

Novel and transgenic food crops: overview of scientific versus public perception.

Transgenic research·1998
Same author

Scientific and ethical issues of preimplantation diagnosis.

Annals of medicine·1998
Same author

Geographic variations of life history strategies in Drosophila melanogaster. III. New data.

Experimental gerontology·1996
Same author

Selection for increased longevity in Drosophila melanogaster: reflections on new data.

Gerontology·1996

Related Experiment Video

Updated: Feb 10, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.2K

[Aging: genetic aspects].

F A Lints

    Acta Psychiatrica Belgica
    |July 1, 1983
    PubMed
    Summary

    Genetic factors likely determine aging and lifespan, challenging prevailing stochastic theories. Despite widespread belief, current evidence for genetic determinism in aging remains limited, requiring further investigation.

    Area of Science:

    • Gerontology
    • Genetics
    • Molecular Biology

    Context:

    • Theories of aging have predominantly focused on stochastic processes for the past 25 years.
    • A paradox exists between the acknowledgment of genetic influence on aging and the prevalence of stochastic theories.
    • Gerontological research has historically grawppled with the interplay of genetic and environmental factors in aging.

    Purpose:

    • To critically review the evidence supporting stochastic theories of aging.
    • To evaluate the existing evidence for a genetic basis of aging and lifespan.
    • To highlight the current limitations in definitively proving genetic determinism in the aging process.

    Summary:

    • Stochastic theories of aging, despite their prevalence, are likely incorrect based on current evidence.

    More Related Videos

    A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
    09:37

    A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

    Published on: July 14, 2016

    8.8K
    Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
    14:09

    Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

    Published on: March 18, 2010

    18.5K

    Related Experiment Videos

    Last Updated: Feb 10, 2026

    Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
    11:57

    Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

    Published on: November 26, 2017

    9.2K
    A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
    09:37

    A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

    Published on: July 14, 2016

    8.8K
    Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
    14:09

    Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

    Published on: March 18, 2010

    18.5K
  • The evidence supporting a significant genetic determination of aging and lifespan is currently scarce.
  • Definitive proof for genetic determinism in aging has not yet been established.

    • Impact:

    • Challenges the current paradigm in aging research, shifting focus towards genetic underpinnings.
    • Suggests a need for re-evaluation of aging mechanisms and the development of new theoretical frameworks.
    • Opens avenues for future research to explore the genetic basis of aging and lifespan determination.