Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human cellular immune responsiveness following space flight.

G R Taylor, J R Dardano

    Aviation, Space, and Environmental Medicine
    |December 1, 1983
    PubMed
    Summary

    Astronaut immune cells, specifically T lymphocytes, showed reduced function after spaceflight. Increased inflight stress, not microgravity, appears to be the main cause of these immune changes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Quality standards for DNA sequence variation databases to improve clinical management under development in Australia.

    Applied & translational genomics·2016
    Same author

    A feasibility study testing four hypotheses with phase II outcomes in advanced colorectal cancer (MRC FOCUS3): a model for randomised controlled trials in the era of personalised medicine?

    British journal of cancer·2014
    Same author

    Inhibition of thymidylate biosynthesis induces mitotic unequal sister chromatid recombination in Saccharomyces cerevisiae.

    Current genetics·2013
    Same author

    Diagnosis of copy number variation by Illumina next generation sequencing is comparable in performance to oligonucleotide array comparative genomic hybridisation.

    Genomics·2013
    Same author

    Attitudes towards prenatal testing and termination of pregnancy in British Pakistani parents and relatives of children with recessive conditions in the UK.

    Prenatal diagnosis·2012
    Same author

    Automated genotyping in diagnosis.

    Methods in molecular medicine·2011

    Area of Science:

    • Space medicine
    • Immunology
    • Human physiology

    Background:

    • Spaceflight impacts astronaut health, including immune function.
    • Understanding immune system changes during space missions is crucial for crew safety.

    Purpose of the Study:

    • To investigate the effects of spaceflight on peripheral circulating lymphocytes.
    • To determine the role of stress versus hypogravity in observed immune alterations.

    Main Methods:

    • Blood samples collected from astronauts before and after space shuttle flights.
    • In vitro analysis of T lymphocyte response to Phytohemagglutinin (PHA) by blastogenesis.
    • Quantification of leukocyte counts (neutrophils, eosinophils) postflight.

    Main Results:

    • Reduced T lymphocyte blastogenesis observed in astronauts post-spaceflight.
    • Postflight increase in neutrophils and decrease in eosinophils noted.
    • Immune changes correlated with subjective reports of inflight stress.

    Conclusions:

    • Inflight stress, rather than hypogravity, is likely the primary driver of leukocyte alterations.
    • Stress management may be key to mitigating immune dysregulation during space missions.

    Related Experiment Videos