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[A method for erythrocyte filtration].

D Boeri, U Armani, R Cordera

    Bollettino Della Societa Italiana Di Biologia Sperimentale
    |October 30, 1983
    PubMed
    Summary
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    Erythrocyte deformability, crucial for blood viscosity, was assessed using a novel filtration method. This technique aids in understanding altered microcirculation by evaluating red blood cell filtration.

    Area of Science:

    • Hematology
    • Biophysics

    Context:

    • Erythrocyte deformability significantly influences blood viscosity.
    • Altered blood viscosity is implicated in microcirculation damage.

    Purpose:

    • To introduce and validate a method for assessing erythrocyte deformability using Nucleopore membranes.
    • To establish normal ranges for erythrocyte filtration in healthy young adults.

    Summary:

    • The study details a filtration method using Nucleopore membranes to evaluate erythrocyte deformability.
    • Filtration time (sec/ml) was measured for five filtrations per subject and correlated with hematocrit.
    • Normal ranges were determined in young, healthy individuals.

    Impact:

    • While the method presents utilization challenges, it offers valuable insights into the role of erythrocyte deformability in microcirculation.

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  • This research contributes to understanding the pathophysiology of conditions involving altered blood flow.