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Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Cells of the Adaptive Immune Response

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Related Experiment Video

Updated: Jul 19, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

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Published on: May 27, 2015

Bone-marrow mast cells in lymphoproliferative disorders.

D Yoo, L S Lessin, W N Jensen

    Annals of Internal Medicine
    |June 1, 1978
    PubMed
    Summary

    Bone marrow mast cell counts are elevated in lymphoproliferative disorders like chronic lymphocytic leukemia and non-Hodgkin

    Area of Science:

    • Hematology
    • Oncology
    • Pathology

    Background:

    • Previous studies suggest a link between increased bone marrow mast cells and lymphoproliferative disorders.
    • Mast cells are immune cells found in various tissues, including bone marrow.

    Purpose of the Study:

    • To investigate bone marrow mast cell content in patients with multiple myeloma, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and reactive lymphocytosis.
    • To determine if mast cell content can aid in diagnosing lymphoproliferative disorders.

    Main Methods:

    • A semiquantitative method was used to assess bone marrow mast cell content.
    • 120 bone marrow specimens were analyzed from patients with various hematologic conditions and iron-deficient controls.

    Main Results:

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    • Significantly increased mast cell content was observed in chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and reactive lymphocytosis compared to controls (p ≤ 0.0005).
    • Multiple myeloma patients exhibited decreased mast cell content, distinguishing them from lymphoproliferative disorders.
    • A direct correlation was found between mast cell content and the percentage of marrow lymphocytes.

    Conclusions:

    • Bone marrow mast cell content is elevated in most lymphoproliferative disorders.
    • Mast cell density correlates with the degree of lymphoid proliferation.
    • Measuring bone marrow mast cells can support the diagnosis of lymphoproliferative disorders and differentiate them from multiple myeloma.