Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subacute sclerosing panencephalitis: fundus changes and histopathologic correlations.

J J De Laey, M Hanssens, P Colette

    Documenta Ophthalmologica. Advances in Ophthalmology
    |December 15, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Guideline on Pelvic Floor Disorders: consensus on Obstructed Defecation Syndrome (ODS).

    Acta gastro-enterologica Belgica·2026
    Same author

    Aneuploidy screening in women of advanced age in the public healthcare setting of a low- to middle- income country - an observational cohort study.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
    Same author

    Corrigendum: Cemiplimab for advanced cutaneous squamous cell carcinoma in kidney transplant recipients.

    Frontiers in nephrology·2025
    Same author

    Trisomy 21 screening with αlpha software and the Fetal Medicine Foundation algorithm.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
    Same author

    Cemiplimab for advanced cutaneous squamous cell carcinoma in kidney transplant recipients.

    Frontiers in nephrology·2023
    Same author

    Impact of fetal growth restriction on pregnancy outcome in women undergoing expectant management for preterm pre-eclampsia.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023

    Subacute sclerosing panencephalitis (SSPE) can manifest with ocular findings before neurological symptoms appear. Early detection of these fundus changes is crucial for timely SSPE diagnosis.

    Area of Science:

    • Ophthalmology
    • Neurology
    • Virology

    Background:

    • Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disorder.
    • Ocular manifestations can precede neurological symptoms in SSPE.
    • Early diagnosis is critical for managing SSPE progression.

    Observation:

    • Two patients with SSPE presented with distinct fundus changes.
    • Ocular findings appeared months before the onset of neurological signs.
    • One patient showed macular serous detachment with retinal infiltrates; the other had atypical macular chorioretinitis.

    Findings:

    • SSPE diagnosis was confirmed by EEG and elevated measles antibodies in serum and cerebrospinal fluid (CSF).
    • Histopathology of one affected eye revealed pigment epithelial changes, external plexiform layer edema, retinal folds, and internal limiting membrane abnormalities.

    Related Experiment Videos

  • The ocular findings were indicative of a viral encephalitis process.

    • Implications:

    • Ophthalmological examination is vital for identifying early signs of SSPE.
    • Recognizing these specific fundus changes can aid in earlier diagnosis and intervention.
    • Understanding the ocular pathology provides insights into SSPE pathogenesis.