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Summary
Piroxicam transfers into breast milk at low levels (1% of maternal serum concentration) in nursing mothers. Infant serum analysis showed no detectable levels of the drug, suggesting minimal infant exposure.
Area of Science:
- Pharmacology
- Neonatal Medicine
- Lactation Studies
Background:
- Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation.
- Assessing drug transfer into breast milk is crucial for infant safety during maternal medication use.
Observation:
- Two lactating women participating in the study were administered piroxicam.
- Breast milk and maternal serum samples were collected for analysis.
Findings:
- Piroxicam was detected in breast milk at approximately 1% of the concentration found in maternal serum.
- No detectable levels of piroxicam were found in the serum of an infant breastfed by one of the participants.
Implications:
- The low transfer of piroxicam into breast milk suggests a potentially low risk for breastfeeding infants.
- Further research may be warranted to confirm these findings in a larger cohort.
- This data can inform clinical decisions regarding NSAID use in nursing mothers.