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Related Experiment Videos

Calcium channel blockade by certain opioids.

D E Seyler, J L Borowitz, R P Maickel

    Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
    |November 1, 1983
    PubMed
    Summary

    Verapamil enhanced morphine pain relief, but not methadone or propoxyphene. Methadone and propoxyphene, like verapamil, block calcium channels, explaining these differing effects.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Toxicology

    Background:

    • Verapamil, a calcium channel blocker, potentiates morphine analgesia.
    • Methadone and propoxyphene analgesia are unaffected by verapamil.
    • This suggests differing mechanisms of action for these opioids.

    Purpose of the Study:

    • To investigate the hypothesis that methadone and propoxyphene block calcium channels, unlike morphine.
    • To elucidate the role of calcium channel blockade in the pharmacological and toxicological profiles of these opioids.

    Main Methods:

    • Assessed effects of verapamil, methadone, propoxyphene, morphine, and procaine on calcium-dependent catecholamine release and smooth muscle contractions.
    • Examined cardiovascular effects (bradycardia, hypotension, tachycardia, hypertension) in spinal vagotomized rats.

    Main Results:

    • Verapamil, methadone, and propoxyphene inhibited calcium-dependent catecholamine release and ileal contractions; morphine and procaine did not.
    • Calcium reversed the inhibitory effects of opioids.
    • Methadone, propoxyphene, and verapamil caused bradycardia and hypotension, while morphine caused tachycardia and hypertension in rats.

    Conclusions:

    • Methadone and propoxyphene, distinct from morphine, exhibit verapamil-like calcium channel blockade.
    • Differences in verapamil-like calcium channel blockade contribute to the pharmacological and toxicological variations among these opioids.

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