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Thyroid function in patients with breast cancer.

M Perry, D J Goldie, M Self

    Annals of the Royal College of Surgeons of England
    |July 1, 1978
    PubMed
    Summary
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    Breast cancer patients often exhibit hypothyroidism, indicated by lower free thyroxine index and higher thyroid-stimulating hormone levels. These thyroid function changes worsen over six months, suggesting a progressive decline in thyroid health.

    Area of Science:

    • Endocrinology
    • Oncology

    Background:

    • Thyroid dysfunction is a common endocrine disorder.
    • Breast cancer is a prevalent malignancy in women.

    Purpose of the Study:

    • To investigate thyroid function in breast cancer patients.
    • To compare thyroid function between breast cancer patients and a healthy control group.

    Main Methods:

    • Assessed thyroid function in 40 breast cancer patients.
    • Compared results with an age-matched female control population.

    Main Results:

    • Breast cancer patients had a lower free thyroxine index.
    • Elevated serum thyroid-stimulating hormone levels were observed in cancer patients.
    • These thyroid function alterations became more pronounced at 6 months.

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    Conclusions:

    • Patients with breast cancer demonstrate increased evidence of hypothyroidism.
    • Thyroid function declines progressively over time in breast cancer patients.