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[Acute alcoholic hepatitis and death of cirrhotic patients]
Insights
Alcoholic hepatitis (AH) is less frequent in cirrhotic patients than previously thought. This study found AH patients exclusively died from liver-related complications, unlike non-AH patients.
Area of Science:
- Hepatology
- Gastroenterology
- Pathology
Context:
- Cirrhosis is a significant cause of mortality worldwide.
- The role of alcoholic hepatitis (AH) in cirrhotic patient deaths requires further clarification.
- Previous studies may have overestimated the prevalence and impact of AH in cirrhosis.
Purpose:
- To investigate the causes of death in cirrhotic patients.
- To determine the prevalence of alcoholic hepatitis (AH) in cirrhosis.
- To characterize the clinical and laboratory features of cirrhotic patients with AH.
Summary:
- A necropsy-based study of 107 cirrhotic patients without hepatocellular carcinoma revealed AH in 26% of cases.
- Severe liver failure, hemorrhage, and infection were the primary causes of death in cirrhotic patients.
- Patients with AH exclusively died from liver disease complications, whereas 21.5% of non-AH patients died from unrelated causes.
Impact:
- This research refines the understanding of mortality causes in cirrhosis.
- It highlights the distinct clinical and laboratory profiles of cirrhotic patients with and without AH.
- Findings suggest AH may be a more direct determinant of mortality in cirrhosis than previously recognized.
Abstract:
Alcoholic hepatitis (AH) seems to be less frequent and to play a lesser role in the death of cirrhotic patients than previously acknowledged. The purpose of this work was: 1) to study the cause of death of cirrhotic patients 2) to determine the prevalence of AH among these patients and 3) to describe the clinical and laboratory features of cirrhotic patients with AH. The data were collected from a series of 107 necropsies in cirrhotic patients without hepatocellular carcinoma. The statistical analyses were carried out with an IRIS 80 computer. Severe liver failure with jaundice and encephalopathy, hemorrhage and uncontrolled infection with septic shock represented 84 p. 100 of the causes of death in patients with cirrhosis. Seventy-nine out of 107 patients (74 p. 100) had no AH (group 1), and 28 (26 p. 100) had AH (group 2): AH was mild in 15 cases and severe in 13 cases. All patients with AH died from a complication directly related to their liver disease while 21.5 p. 100 of patients without AH died from a complication not related to cirrhosis. The clinical and laboratory features of the patients without AH and cirrhosis differed from those of patients without AH by: a more frequent presence of fever (p less than 0.01), the absence of important weight loss (p less than 0.001), the total absence of abstinence (p less than 0.05), a higher value of ASAT/ALAT ratio, of serum levels of total bilirubin (p less than 0.01) and conjugated bilirubin (p less than 0.05), gamma glutamyl transpeptidase (p less than 0.001) and total cholesterol (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)