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[Effects of methysergide on pulmonary circulation]
[Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science
|September 1, 1983
Summary
Methysergide, a serotonin antagonist, affects the pulmonary circulation by increasing pulmonary arterial pressure and resistance, similar to serotonin. This suggests methysergide may act as a partial agonist on pulmonary serotonin receptors.
Area of Science:
- Cardiovascular Physiology
- Pharmacology
Context:
- Pulmonary circulation regulation is complex.
- Serotonin plays a role in vascular tone.
- Understanding drug effects on pulmonary circulation is crucial.
Purpose:
- To investigate the effects of methysergide on canine pulmonary circulation.
- To determine if methysergide exhibits serotonin-like effects.
- To assess methysergide's potential as a partial agonist.
Summary:
- Methysergide administration increased pulmonary arterial pressure and resistance in dogs.
- Higher doses of methysergide decreased heart rate and aortic pressure.
- Methysergide blocked serotonin's effect on pulmonary vascular resistance and impedance.
Impact:
- Methysergide exhibits serotonin-like effects on the pulmonary circulation.
- Findings suggest methysergide may act as a partial agonist on pulmonary serotonin receptors.
- This research aids in understanding the role of serotonin antagonists in pulmonary circulatory disturbances.